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  1. Down syndrome - Wikipedia

    Down syndrome or Down's syndrome, [12] also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. [3]

  2. Down syndrome - Symptoms and causes - Mayo Clinic

    Nov 12, 2024 · Down syndrome is a genetic condition caused when an unusual cell division results in an extra full or partial copy of chromosome 21. This extra genetic material causes the developmental …

  3. Down Syndrome | Birth Defects | CDC

    Dec 26, 2024 · Down syndrome is a condition in which a person has an extra copy of chromosome 21. Chromosomes are small "packages" of genes in the body's cells, which determine how the body …

  4. About Down Syndrome - National Human Genome Research Institute

    Jun 29, 2017 · Having an extra number 21 chromosome interrupts the normal course of development, causing the characteristic clinical features of Down syndrome. Some people who have Down …

  5. Down syndrome - Harvard Health

    Jun 25, 2025 · Down syndrome is a disorder caused by having an extra chromosome. Chromosomes are pieces of DNA that have the blueprint for the human body. Normally a person has two copies of …

  6. Down syndrome | Definition, Chromosome, Symptoms, Causes, & Life ...

    Nov 21, 2025 · Down syndrome, congenital disorder caused by the presence in the human genome of extra genetic material from chromosome 21. The affected individual may inherit an extra part of …

  7. Down Syndrome (Trisomy 21) - Children's Health Issues - MSD …

    Down syndrome is caused by an extra chromosome 21. Children with Down syndrome have delayed physical and mental development, specific head and facial features, and are often short.

  8. What Chromosome Causes Down Syndrome? | Clear Genetic Facts

    In Down syndrome, there is an extra copy of chromosome 21, resulting in three copies instead of the usual two. This abnormality disrupts normal development and leads to the characteristic features and …

  9. Down Syndrome - Boston Children's Hospital

    Down syndrome is a genetic condition that happens when a child is born with an extra chromosome. The extra chromosome affects the way the child’s brain and body develop, leading to developmental …

  10. Down syndrome - PMC

    Down syndrome (DS) is the most common genomic disorder of intellectual disability and is caused by trisomy of Homo sapiens chromosome 21 (HSA21). The eponym of the syndrome is from Down, who …